Power and Sample Size Calculations for Primary Open Angle Glaucoma/Ocular Hypertension Clinical Trials Accounting for Correlation of Measures among the Time Points across Visits
ARVO Annual Meeting, May 2014
Poster
Historically, the correlation among time points within a subject/eye and the requirement of a majority of time points having an upper 95% Confidence Interval less than 1 mmHg has not been overtly accounted for when determining power and sample size for clinical trials in primary open angle glaucoma/ocular hypertension. We propose a method to account for both of these points.
This poster details:
- The importance of accounting for the correlation of measures among time points
- How the number of time points and correlation among time points affect power and sample size
- How these variables affect Type I Error
Authored by:
- Dale Usner, PhD
- Richard Abelson, PhD