Power and Sample Size Calculations for Primary Open Angle Glaucoma/Ocular Hypertension Clinical Trials Accounting for Correlation of Measures among the Time Points across Visits
ARVO Annual Meeting, May 2014
ARVO Annual Meeting, May 2014
Historically, the correlation among time points within a subject/eye and the requirement of a majority of time points having an upper 95% Confidence Interval less than 1 mmHg has not been overtly accounted for when determining power and sample size for clinical trials in primary open angle glaucoma/ocular hypertension. We propose a method to account for both of these points.