Power and Sample Size Calculations for Primary Open Angle Glaucoma / Ocular Hypertension Clinical Trials Accounting for Correlation of Measures among the Time Points across Visits

Jul 10, 2018 | Publications and Posters

ARVO Annual Meeting, May 2012


Historically, the correlation among time points within a subject/eye and the requirement of a majority of time points having an upper 95% Confidence Interval less than 1 mmHg has not been overtly accounted for when determining power and sample size for clinical trials in primary open angle glaucoma/ocular hypertension. We propose a method to account for both of these points.

This poster details:

  • The importance of accounting for the correlation of measures among time points
  • How the number of time points and correlation among time points affect power and sample size
  • How these variables affect Type I Error

Authored by:

  • Dale Usner, PhD
  • Richard Abelson, PhD

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